Cancer module

Hematologic · Lymphoma & Leukemia

Lugano-classified lymphoma + myeloid-leukemia work-up with CBC + flow cytometry.

Reporting system
Lugano classification (lymphoma) / ELN risk (AML)
Imaging modalities
  • CBC + peripheral smear
  • Flow cytometry
  • PET-CT (Lugano)
  • Bone-marrow biopsy
Key findings OCTON surfaces
  • Painless lymphadenopathy > 4 weeks
  • Cytopenias with circulating blasts
  • Mediastinal mass + B-symptoms
  • Splenomegaly / hepatomegaly without infection
  • Monoclonal gammopathy on SPEP
Evidence base
  • NCCN B-cell Lymphomas v3.2025
  • ELN AML Recommendations 2022
  • NCCN CLL/SLL v2.2025
Risk questionnaire
  • · What is your age?
  • · First-degree relative with leukemia / lymphoma / myeloma?
  • · Prior chemotherapy or radiation (therapy-related risk)?
  • · Significant benzene / petroleum exposure?
  • · Chronic immunosuppression / HIV?
  • · History of Epstein-Barr / HTLV-1 / HCV?
  • · Unexplained fevers, night sweats, or > 10% weight loss?
See OCTON in action · early-detection demos
15 / 24
Hematologic · DLBCLYou're herehigh · 78/100PET-CT · Lugano III
Diffuse large B-cell lymphoma · Lugano III
Multi-station lymphadenopathy with FDG-avid mediastinal + axillary + inguinal nodes — biopsy confirmed DLBCL Lugano III.
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