Cancer module

Gastric Cancer

EGD surveillance for high-risk hosts (H. pylori, hereditary diffuse gastric).

Reporting system
Paris / Lauren classification + AJCC T-stage
Imaging modalities
  • Upper Endoscopy (EGD)
  • Endoscopic Ultrasound
  • CT abdomen/pelvis
  • H. pylori testing
  • Histopathology
Key findings OCTON surfaces
  • Asymmetric / nodular gastric-fold thickening
  • Borrmann type-IV linitis plastica appearance
  • Ulcerated mass with raised margins
  • Gastric outlet obstruction
  • Krukenberg metastasis on pelvic imaging
Evidence base
  • NCCN Gastric Cancer v2.2025
  • ACG Guidelines on H. pylori 2024
  • Hereditary Diffuse Gastric Cancer (CDH1) Consortium 2020
Risk questionnaire
  • · What is your age?
  • · Active or treated H. pylori infection?
  • · Known CDH1 (hereditary diffuse gastric) mutation?
  • · First-degree relative with gastric cancer?
  • · Current or former smoker?
  • · Pernicious anaemia / autoimmune gastritis?
  • · Diet high in salted / smoked / preserved foods?
  • · From a high-incidence region (East Asia, Andes, E. Europe)?
See OCTON in action · early-detection demos
12 / 24
Gastric cancerYou're herehigh · 88/100EGD · Lauren / AJCC T1a · diffuse
Signet-ring cell foci on CDH1 surveillance EGD
Multifocal signet-ring foci in random gastric biopsies (T1a) — pre-invasive diffuse-type cancer caught before mass formation.
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