Cancer module

Other / Unspecified

Holistic AI screen — apply when the suspected primary site is unknown or rare.

Reporting system
General radiologic descriptor + organ-specific guideline triage
Imaging modalities
  • CT
  • MRI
  • Ultrasound
  • X-Ray
  • PET-CT
  • Pathology
Key findings OCTON surfaces
  • Mass / lesion of indeterminate origin
  • Lymphadenopathy in a single basin
  • Abnormal contrast enhancement / restricted diffusion
  • Para-neoplastic syndrome with no obvious primary
  • Elevated tumor markers (CEA, CA 19-9, AFP, β-hCG, LDH)
Evidence base
  • Triage per the most relevant organ-system guideline
  • NCCN Occult Primary v1.2025 for cancer-of-unknown-primary work-up
  • ESMO CUP Clinical Practice Guidelines 2023
Risk questionnaire
  • · What is your age?
  • · Sex assigned at birth
  • · First-degree relative with any cancer under age 60?
  • · Known hereditary cancer syndrome (BRCA, Lynch, Li-Fraumeni, NF1, VHL, CDH1, MEN, Cowden, etc.)?
  • · Current or heavy past tobacco use?
  • · Heavy alcohol use (> 3 drinks/day)?
  • · BMI ≥ 30?
  • · HIV+, transplant, or chronic immunosuppression?
  • · Personal history of any prior cancer (second-primary risk)?
  • · Prior therapeutic radiation?
  • · Unexplained weight loss > 5% in 6 months?
  • · Persistent unexplained pain or fatigue > 4 weeks?
  • · Persistent lymph-node swelling > 4 weeks?
  • · Occupational carcinogen exposure (asbestos, benzene, arsenic, formaldehyde, etc.)?
See OCTON in action · early-detection demos
06 / 24
Thyroid · incidentalYou're hereelevated · 50/100US · ACR-TIRADS TR5
Sub-cm hypoechoic thyroid nodule with TIRADS 5 features
8 mm hypoechoic, taller-than-wide thyroid nodule with microcalcifications — TIRADS 5 (highly suspicious).
View demo
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