Cancer module

Pancreatic Cancer

High-risk-cohort surveillance with EUS / MRI and new-onset diabetes triage.

Reporting system
AJCC / PanIN grade
Imaging modalities
  • Contrast-enhanced CT
  • MRI / MRCP
  • Endoscopic Ultrasound (EUS)
  • Pathology
Key findings OCTON surfaces
  • Focal pancreatic duct dilation
  • Hypoattenuating pancreatic mass
  • Abrupt ductal cutoff
  • Parenchymal atrophy upstream of lesion
  • Vascular encasement
Evidence base
  • International CAPS Consortium 2022
  • NCCN Pancreatic Adenocarcinoma v2.2025
  • BMJ 2024;384:e076765 — new-onset diabetes as an early signal
Risk questionnaire
  • · What is your age?
  • · Current smoker, or > 20 pack-year history?
  • · New-onset diabetes after age 50?
  • · History of chronic pancreatitis?
  • · ≥ 2 first-degree relatives with pancreatic cancer?
  • · Known Peutz-Jeghers, HNPCC, FAMMM, or hereditary pancreatitis?
  • · BMI ≥ 30?
  • · Heavy alcohol use (> 3 drinks/day)?
See OCTON in action · early-detection demos
02 / 24
Pancreatic cancerYou're hereelevated · 62/100MRI · Fukuoka Worrisome
Branch-duct IPMN with high-risk stigmata — pre-malignant catch
1.6 cm branch-duct IPMN with mural nodule — worrisome stigmata; pre-malignant lesion identified.
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