OCTON 360
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WHAT OCTON CONSULTS

Every recommendation OCTON gives is traceable to a peer-reviewed source.

We don't guess. The specialist prompts driving OCTON's clinical reasoning reference the society guidelines, peer-reviewed journals, landmark trials and standard textbooks below — refreshed continuously as evidence updates.

8
Specialty pillars
75
Society guidelines
51
Landmark trials
BY SPECIALTY

One catalogue per clinical pillar.

Society guidelines
  • AHA / ACC 2024 — Multisociety Chronic Coronary Disease guideline
  • AHA / ACC 2019 — Primary Prevention of Cardiovascular Disease
  • AHA / ACC 2018 — Cholesterol Management (PCSK9 + statin escalation)
  • ESC 2023 — Acute Coronary Syndromes
  • ESC 2024 — Hypertension
  • ESC 2024 — Atrial Fibrillation
  • AHA 2023 — Cardiopulmonary Resuscitation & ECC
  • ASE 2019 — Chamber Quantification in echocardiography
  • USPSTF 2022 — Statins for Primary Prevention
  • USPSTF 2018 — Aspirin for CVD Primary Prevention
Journals consulted
  • New England Journal of Medicine — NEJM
  • Journal of the American College of Cardiology — JACC
  • Circulation
  • European Heart Journal
  • The Lancet
  • JAMA Cardiology
  • Heart (BMJ)
  • Circulation: Heart Failure
Landmark trials
  • MERIT-HF (1999) — metoprolol-CR in heart failure
  • EMPHASIS-HF (2011) — eplerenone in mild HF
  • DAPA-HF (2019) — dapagliflozin in HFrEF
  • EMPEROR-Reduced (2020) — empagliflozin in HFrEF
  • PARADIGM-HF (2014) — sacubitril/valsartan
  • ISCHEMIA (2020) — invasive vs conservative chronic CAD
  • FOURIER (2017) — evolocumab CV outcomes
  • PROMISE & SCOT-HEART — CT coronary angiography
  • CACS — coronary artery calcium scoring (MESA & ATTICA cohorts)
  • ASCVD Pooled Cohort Equations — Goff et al, 2013
EVIDENCE PYRAMID

Strongest-evidence-first weighting.

When OCTON's specialist debate finds conflicting evidence, the Evidence-review audit pair down-weights weaker tiers automatically. You see the citation tier on every recommendation.

  1. 1Systematic reviews · meta-analyses (Cochrane, AHRQ)
  2. 2Randomised controlled trials (NEJM, JAMA, Lancet)
  3. 3Society guidelines (USPSTF, NCCN, AHA, ESMO, AAN, AAD, APA, AAP)
  4. 4Prospective cohort studies & registries
  5. 5Case-control & cross-sectional studies
  6. 6Expert consensus & textbook references
STANDARD TEXTBOOKS

Ten standard medical textbooks.

  • Harrison's Principles of Internal Medicine (21st ed)
  • Robbins & Cotran Pathologic Basis of Disease (10th ed)
  • Goldman-Cecil Medicine (27th ed)
  • Nelson Textbook of Pediatrics (22nd ed)
  • Adams & Victor's Principles of Neurology (12th ed)
  • DeVita, Hellman & Rosenberg's Cancer (12th ed)
  • Braunwald's Heart Disease (12th ed)
  • Fitzpatrick's Dermatology (9th ed)
  • Kaplan & Sadock's Synopsis of Psychiatry (12th ed)
  • Goodman & Gilman's The Pharmacological Basis of Therapeutics (14th ed)
REFRESH CADENCE

Continuously refreshed.

  • Society guideline editions — refreshed within 30 days of release
  • NCCN — versioned quarterly
  • USPSTF — refreshed on the day of new evidence release
  • Drug interaction tables — synced daily with Lexicomp & DDInter
  • Landmark-trial library — manually curated quarterly
SEE IT YOURSELF

Try a consult — every recommendation will cite the source.

Start a consult