OCTON 360
Sign up
Early-detection demo · Cervical cancer

HSIL caught from persistent HPV-16 + colposcopy

High-grade squamous intraepithelial lesion (HSIL · CIN 2-3) on directed colposcopy biopsy — pre-invasive disease curable with LEEP.

Patient: Sofia · 34 · HPV-16 persistentModality: ColposcopyRisk: high · 71/100
Share
01

Risk profile

What OCTON knew before the scan
Risk
71
high
Tier
high
Mother of 2 · partner with prior penile HPV-related lesion · last Pap age 28 (ASC-US, lost to follow-up) · HPV-16+ × 2 years.
Contributing factors
  • Persistent HPV-16 ++32
  • Prior ASC-US lost to follow-up+14
  • Active smoker (8 pack-years)+10
  • No HPV vaccination+8
  • Age 34+4
Narrative

Persistent HPV-16 carries the highest oncogenic potential of any HPV subtype. Combined with smoking, Sofia's risk of progression to invasive cervical cancer over 10 years is substantially elevated. LEEP is curative for confirmed HSIL.

02

Scan + AI report

What Colposcopy found · Colposcopy with acetic-acid + Lugol's iodine
Colposcopy · DEMO
Bethesda HSIL
OCTON · scanning · live
conf 0.85
OCTON Impression · 81% confidence

Acetowhite epithelium occupying ~50% of the transformation zone with mosaic + punctation pattern. No abnormal vasculature suggestive of invasion. Findings consistent with HSIL (CIN 2-3).

Findings
  • Acetowhite epithelium, dense, ~50% TZ · Cervical TZ
  • Mosaic + punctation vessels (G2 pattern) · Anterior cervix
  • Iodine-negative on Lugol's · Whole TZ
Differential diagnosis
  • HSIL (CIN 2-3)70%
  • LSIL with metaplasia18%
  • Microinvasive carcinoma8%
  • Reactive metaplasia4%
Recommended actions
  • ▸LEEP (loop electrosurgical excision) within 4 weeks
  • ▸Co-test (HPV + cytology) at 6 months and 12 months post-LEEP
  • ▸Smoking cessation referral
  • ▸Catch-up HPV vaccination if eligible
Caveats
  • Colposcopy + biopsy under-grades up to 10% of cases — final pathology may upstage to early invasion.
  • HSIL is curable; persistent HR-HPV after LEEP requires lifelong surveillance.
03

360° Preventative plan

Drugs · surveillance · diet · exercise · lifestyle — generated for this case
Clinical anchors
Drugs · labs · imaging · surveillance
Medical
Primary HPV / co-test
FrequencyEvery 5 years
Startsage 25
USPSTF 2018 · Grade A
Medical
LEEP for HSIL
FrequencyOnce
Startsage 25
WHO Cervical Cancer Elimination 2030
Monitoring
Colposcopy + biopsy on HR-HPV+
FrequencyOnce on persistence
Startsage 25
ASCCP 2019
04

What changed

The early-detection win

Persistent HPV-16 + a missed Pap follow-up turned into a curable HSIL — LEEP within 4 weeks averts a future invasive cancer.

Run this for yourself

Open the cervical cancer module on your own data.

Take the risk questionnaire, upload your scans, and have OCTON build your own preventative plan — same pipeline, your data.

Cancer module →Get started